ABSTRACT
Objective] To observe the effect of combined treatment of small doses simvastatin and irbesartan for carotid intima-media thickness ( IMT ) in patients with mild-to-moderate hypertension and normal serum lipid level. [ Methods] A total of 124 patients with mild-to-moderate hypertension and normal serum lipid level were randomly divided into the observation group ( simvastatin combined with irbesartan) of 64 cases and the irbesartan group of 60 cases.Three months were as a course of treatment, and each patient in both groups received two courses;IMT,blood pressure and blood lipids were compared in the two groups before and after treatment. [ Results] After treatment of six months,systolic and diastolic blood pressure, IMT in both groups were significantly decreased, and IMT in the observation group was low-er than that in the control group ( all P<0.05) .In observation group, TC and LDL-C levels were signifi-cantly decreased, and HDL-C level was significantly increased (all P<0.01). [Conclusion] Besides lowering blood pressure and blood lipids levels, combined treatment of small doses simvastatin and irbesar-tan has good reverse effect on increased IMT and improves carotid atherosclerosis in patients with mild-to-moderate hypertension and normal serum lipid level.
ABSTRACT
Objective] To evaluate the influence of metabolic syndrome ( MS) on carotid intima-media thickness ( IMT) in essential hypertension ( EH) . [ Methods] A total of 168 young and middle-aged EH patients were divided into MS group (88 cases) and non-MS group (80 cases).Between the two groups were measured and compared IMT , body mass index ( BMI ) , waist circumference ( WC ) , systolic blood pressure ( SBP ) , diastolic blood pressure ( DBP ) , fasting plasma glucose ( FPG ) , total cholesterol (TC),triglyceride (TG),high-density lipoprotein (HDL-C),low-density lipoprotein (LDL-C) and others. [ Results] Comparison between MS group and non-MS group showed that the level of BMI , FPG, WC, TC, TG, LDL-C and IMT were higher in MS group,P all <0.05.Multiple Logistic regression analysis showed that age,SBP,FPG and LDL-C were the related factors for carotid IMT. [Conclusion] MS is associated with carotid IMT in young and middle-aged patients with EH .MS and EH may jointly participate in the process of atherosclerosis .Apart from control of blood pressure , correction of metabolic disorders is also necessary in order to prevent complication of atherosclerosis .